The ICD-10-CM (International Classification of Diseases, Tenth Revision, Clinical Modification) coding system, a critical standard for classifying diagnoses and inpatient procedures, is undergoing significant updates for Fiscal Year 2025. These changes, effective October 1, 2024, include 252 new codes, 13 deletions, and 36 revisions, reflecting the latest advancements in healthcare. These updates are essential for accurate clinical documentation, billing, and tracking patient care.
Key Highlights of the 2025 ICD-10-CM Codes Updates:
1. Diabetes Updates: Three new codes (E10.A10–E10.A12) were added to identify presymptomatic Type 1 Diabetes, emphasizing early diagnosis. Additionally, three new codes for hypoglycemia levels (E16.A1–E16.A3) were introduced.
2. Lymphoma in Remission: Sixty-three new codes were added to specify lymphoma in remission, enabling better tracking of patient care and resource utilization.
3. Fanconi Anemia: A new code (D61.03) was introduced for this rare genetic disorder, allowing for improved tracking and classification as a Complication/Comorbidity (CC).
4. Personal History of Polyps: Four new codes (Z86.0100–Z86.0102 and Z86.0109) were added to classify non-neoplastic and neoplastic polyps, aiding in risk assessment.
5. Congenital Heart Conditions: New codes for bicuspid aortic valve (Q23.81) and other congenital heart malformations (Q23.82, Q23.88) were introduced to improve tracking and prevention of complications.
6. Obesity Classifications: Four new codes (E66.811–E66.89) were added to specify different classes of obesity, enabling better monitoring of its health impact.
7. Eating Disorders: Enhanced specificity in anorexia diagnosis codes (F50.010–F50.029) now differentiates between restricting and binge-purge types, with severity levels included.
8. Pulmonary Embolism: Four new codes (I26.03–I26.04 and I26.95–I26.96) were added for fat and cement pulmonary embolism, improving diagnosis and treatment.
9. KCNQ2-Related Epilepsy: Four new codes (G40.43X-) were introduced to address this common genetic epilepsy syndrome in children.
10. Nasal Valve Collapse: Seven new codes (J34.82) were added to differentiate between internal/external and static/dynamic nasal valve collapse.
These updates reflect the evolving needs of healthcare providers and patients, ensuring greater accuracy in diagnosis, treatment, and billing.
Chapter | New Codes | Deletions | Revisions |
Chapter 1: Certain Parasitic and Infectious Diseases | 0 | 0 | 1 |
Chapter 2: Neoplasms | 63 | 14 | 0 |
Chapter 3: Diseases of the Blood and Blood-Forming Organs | 1 | 0 | 0 |
Chapter 4: Endocrine, Nutritional, and Metabolic Diseases | 16 | 2 | 0 |
Chapter 5: Mental, Behavioral and Neurodevelopmental Disorders | 26 | 4 | 1 |
Chapter 6: Diseases of the Nervous System | 7 | 1 | 1 |
Chapter 7: Diseases of the Eye and Adnexa | 0 | 0 | 5 |
Chapter 8: Diseases of the Ear and Mastoid Process | 0 | 0 | 0 |
Chapter 9: Diseases of the Circulatory System | 4 | 0 | 2 |
Chapter 10: Diseases of the Respiratory System | 7 | 0 | 0 |
Chapter 11: Diseases of the Digestive System | 27 | 3 | 1 |
Chapter 12: Diseases of the Skin and Subcutaneous Tissue | 8 | 3 | 0 |
Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue | 33 | 3 | 0 |
Chapter 14: Diseases of the Genitourinary System | 0 | 0 | 0 |
Chapter 15: Pregnancy, Childbirth, and the Puerperium | 0 | 0 | 0 |
Chapter 16: Certain Conditions Originating in the Perinatal Period | 0 | 0 | 0 |
Chapter 17: Congenital Malformations, Deformations, and Chromosomal Abnormalities | 4 | 1 | 1 |
Chapter 18: Symptoms, Signs, and Abnormal Clinical and Laboratory Findings | 1 | 0 | 0 |
Chapter 19: Injury, Poisoning, and Certain Other Consequences of External Causes | 30 | 3 | 0 |
Chapter 20: External Causes of Morbidity | 0 | 0 | 0 |
Chapter 21: Factors Influencing Health Status and Contact with Health Services | 25 | 2 | 1 |
Chapter 22: Codes for Special Purposes | 0 | 0 | 0 |
Read More: 10 Must-ask Questions for Autonomous Medical Coding Vendors

The Role of AI in Keeping Up with ICD-10-CM Updates:
The ICD-10-CM coding system is complex and constantly evolving, with hundreds of changes annually. For medical coding leaders and managers, staying updated is critical to ensure compliance, accurate billing, and optimal patient care. Here’s how AI (Artificial Intelligence) plays a vital role in managing these updates:
1. Automated Code Updates:
– AI systems can automatically integrate new ICD-10-CM codes into electronic health records (EHRs) and coding software, reducing manual effort and minimizing errors.
– This ensures that healthcare providers and coders are always working with the latest codes.
2. Real-Time Alerts and Recommendations:
– AI-powered tools can provide real-time alerts about code changes, ensuring coders and managers are aware of updates as soon as they are implemented.
– AI can also recommend the most appropriate codes based on clinical documentation, improving accuracy and efficiency.
3. Enhanced Training and Education:
– AI-driven platforms can offer personalized training modules for coders, focusing on new codes and revisions. This helps teams stay proficient and compliant.
– Interactive AI tools can simulate coding scenarios, allowing coders to practice using new codes in a risk-free environment.
4. Data Analysis and Insights:
– AI can analyze coding patterns and identify trends, helping managers understand how new codes are being used and whether further training is needed.
– This data-driven approach ensures continuous improvement in coding practices.
5. Streamlined Audits and Compliance:
– AI can automate the auditing process, flagging potential errors or inconsistencies in coding. This reduces the risk of compliance issues and ensures accurate billing.
– By identifying patterns in coding errors, AI can help managers address recurring issues proactively.
6. Improved Patient Care:
– Accurate coding is essential for tracking patient outcomes and resource utilization. AI ensures that new codes are applied correctly, enabling better data collection and analysis.
– This, in turn, supports evidence-based decision-making and improves patient care.
How AI Helps Medical Coding Leaders and Managers:
– Efficiency: AI reduces the time and effort required to implement and adapt to new codes, allowing teams to focus on patient care.
– Accuracy: By minimizing human error, AI ensures that coding is precise, reducing the risk of claim denials and compliance issues.
– Proactive Management: AI provides insights and alerts that help managers stay ahead of changes, ensuring their teams are always prepared.
– Cost Savings: Automated processes and reduced errors lead to significant cost savings for healthcare organizations.
– Scalability: AI solutions can handle large volumes of data, making them ideal for organizations of all sizes.
In conclusion, the 2025 ICD-10-CM updates highlight the need for advanced tools like AI to manage the growing complexity of medical coding. By leveraging AI, medical coding leaders and managers can ensure compliance, improve accuracy, and enhance patient care, all while staying ahead of the curve in an ever-evolving healthcare landscape.
FAQs on ICD-10-CM codes
What are the key changes in the 2025 ICD-10-CM codes?
The 2025 updates include new codes for emerging diseases, revised guidelines, and expanded specificity for existing conditions.
How will the 2025 ICD-10-CM codes updates impact medical coding?
The updates improve diagnostic accuracy and compliance, requiring coders to stay updated on new code sets and documentation guidelines.
When do the 2025 ICD-10-CM codes changes take effect?
The changes will be effective from October 1, 2024, as per the annual ICD-10-CM update cycle.
What specialties are most affected by the 2025 ICD-10-CM codes updates?
Specialties like neurology, cardiology, and infectious diseases will see significant new codes and modifications.
How can medical coders prepare for the 2025 ICD-10-CM changes?
Coders should review official CMS updates, attend training sessions, and use AI-powered coding tools for seamless adaptation.